Biofilm Inhibitor Taurolithocholic Acid Alters Colony Morphology, Specialized Metabolism, and Virulence of Pseudomonas aeruginosa - ePrints Isabella Floyd | March 26, 2026 Biofilm Inhibitor Taurolithocholic Acid Alters Colony Morphology, Specialized Metabolism, and Virulence of Pseudomonas aeruginosaLookup NU author(s): Manuel BanzhafDownloadsFull text for this publication is not currently held within this repository. Alternative links are provided below where available.AbstractCopyright © 2019 American Chemical Society. Biofilm inhibition by exogenous molecules has been an attractive strategy for the development of novel therapeutics. We investigated the biofilm inhibitor taurolithocholic acid (TLCA) and its effects on the specialized metabolism, virulence, and biofilm formation of the clinically relevant bacterium Pseudomonas aeruginosa strain PA14. Our study shows that TLCA alters the specialized metabolism, thereby affecting P. aeruginosa colony biofilm physiology. We observed an upregulation of metabolites correlated to virulence such as the siderophore pyochelin. A wax moth virulence assay confirmed that treatment with TLCA increases the virulence of P. aeruginosa. On the basis of our results, we believe that future endeavors to identify biofilm inhibitors must consider how a putative lead alters the specialized metabolism of a bacterial community to prevent pathogens from entering a highly virulent state.Publication metadataAuthor(s): Condren AR, Kahl LJ, Boelter G, Kritikos G, Banzhaf M, Dietrich LEP, Sanchez LMPublication type: ArticlePublication status: PublishedJournal: ACS Infectious DiseasesYear: 2020Volume: 6Issue: 4Pages: 603-612Print publication date: 10/04/2020Online publication date: 18/12/2019Acceptance date: 09/11/2019ISSN (electronic): 2373-8227Publisher: American Chemical SocietyURL: DOI: 10.1021/acsinfecdis.9b00424PubMed id: 31851822AltmetricsFundingFunder referenceFunder name1500368American Society for Pharmacognosy research startup grantK12HD055892National Institutes of Health Office of Research on Women’s HealthNIH/NIAIDNational Institute of Child Health and Human Development (NICHD)NSF CAREER AwardR01AI103369University of Illinois at Chicago Startup FundsShare
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